Deriving fast setting properties of tetracalcium phosphate/dicalcium phosphate anhydrous bone cement with nanocrystallites on the reactant surfaces

Wang, Jen-Chyan; Ko, Chia-Ling; Hung, Chun-Cheng; Tyan, Yu-Chang; Lai, Chern-Hsiung; Chen, Wen-Cheng; Wang, Chih-Kuang

doi:10.1016/j.jdent.2009.10.001

« Previous Next »Journal of Dentistry
Volume 38, Issue 2 , Pages 158-165, February 2010

Deriving fast setting properties of tetracalcium phosphate/dicalcium phosphate anhydrous bone cement with nanocrystallites on the reactant surfaces

Jen-Chyan Wang
- School of Dentistry, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan, ROC
- Division of Prosthodontics, Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan, ROC
Chia-Ling Ko
- School of Dentistry, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan, ROC
Chun-Cheng Hung
- School of Dentistry, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan, ROC
- Division of Prosthodontics, Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan, ROC
Yu-Chang Tyan
- National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center, Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan, ROC
Chern-Hsiung Lai
- School of Dentistry, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan, ROC
Wen-Cheng Chen
- School of Dentistry, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan, ROC
- Department of Oral Hygiene, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan, ROC
- Corresponding author at: School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, No. 100 Shih-Chuan 1st Rd., 807 Kaohsiung City, Taiwan, ROC. Tel.: +886 73121101x2158; fax: +886 73210637.
Chih-Kuang Wang
- Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, 807 Kaohsiung City, Taiwan, ROC

Received 20 November 2008; received in revised form 5 June 2009; accepted 1 October 2009. published online 12 October 2009.

Abstract

Objective

This study attempts to reveal how nanocrystallites on the ceramic surfaces of non-dispersive calcium phosphate cement (nd-CPC) participate in setting processes as compared with conventional CPC (c-CPC).

Methods

The compositions and morphologies of CPC during the early setting reactions were studied with X-ray diffraction and a scanning transmission electron microscope equipped with an energy dispersive spectroscopy system. The pH values and dispersive properties of CPC during the early setting reactions were investigated as well as the compressive strength of nd-CPC after 24h of immersion with varying liquid to powder ratios.

Results

The mechanical strength of nd-CPC was approximately 60MPa after a 24h immersion in simulate body solution with a P/L ratio between 3.3 and 4.2g/mL. The nanocrystallites on the particle surfaces of nd-CPC were shown to grow rapidly and provided interlocking sites that allowed rapid development of the apatite phase in the cement, and were also shown to be non-dispersive in solution as determined by an injection test of c-CPC.

Conclusions

The interlocking particles produced by whisker growth on the ceramic particles or new crystallites formed between the ceramic particles caused the cement to be non-dispersive in solution. The particles of reactants with nanocrystallites on surfaces also gave this cement the ability to be shaped easily as a paste during an operation or to be injected into a cavity.

Keywords: Calcium phosphate, Nanocrystallites, Surfaces, Apatite, Bone cement