Journal of Dentistry
Volume 37, Issue 2 , Pages 93-97 , February 2009

The use of lidocaine as an anti-inflammatory substance: A systematic review

  • Hugo Cesar Pinto Marques Caracas

      Affiliations

    • Department of Orthodontic and Pediatric Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    • Corresponding Author InformationCorresponding author at: SQN 108 Bl A Apt 407, 70744010 Brasília, DF, Brazil.
    • ,
  • José Vinícius Bolognesi Maciel

      Affiliations

    • Department of Orthodontic and Pediatric Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    • ,
  • Patrícia Machado Rodrigues e Silva Martins

      Affiliations

    • Inflammation Laboratory, FIOCRUZ, Avenue Brasil, 4365 Manguinhos, Rio de Janeiro, RJ, Brazil
    • ,
  • Margareth Maria Gomes de Souza

      Affiliations

    • Department of Orthodontic and Pediatric Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
    • ,
  • Lucianne Cople Maia

      Affiliations

    • Department of Orthodontic and Pediatric Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

Received 27 May 2008 ,Revised 14 August 2008 ,Accepted 17 October 2008.

References 

  1. Catterall W, Mackie K. Local anesthetics. In:  Hardman J,  Limbird L editor. The pharmacological basis of theraupetics. McGraw-Hill; 1996;p. 331–347
  2. Rimback G, Cassuto J, Wallin G, Westlander G. Inhibition of peritonitis by amide local anesthetics. Anesthesiology. 1988;69:881–886
  3. Taniguchi T, Shibata K, Yamamoto K, Kobayashi T, Saito K, Nakanuma Y. Lidocaine attenuates the hypotensive and inflammatory responses to endotoxemia in rabbits. Critical Care Medicine. 1996;24:642–646
  4. Hollmann MW, Durieux ME. Local anesthetics and the inflammatory response: a new therapeutic indication?. Anesthesiology. 2000;93:858–875
  5. Sinclair R, Eriksson AS, Gretzer C, Cassuto J, Thomsen P. Inhibitory effects of amide local anaesthetics on stimulus-induced human leukocyte metabolic activation, LTB4 release and IL-1 secretion in vitro. Acta Anaesthesiolica Scandinavica. 1993;37:159–165
  6. Yanagi H, Sankawa H, Saito H, Iikura Y. Effect of lidocaine on histamine release and Ca2+ mobilization from mast cells and basophils. Acta Anaesthesiolica Scandinavica. 1996;40:1138–1144
  7. Eriksson AS, Sinclair R, Cassuto J, Thomsen P. Influence of lidocaine on leukocyte function in the surgical wound. Anesthesiology. 1992;77:74–78
  8. Hattori M, Dohi S, Nozaki M, Niwa M, Shimonaka H. The inhibitory effects of local anesthetics on superoxide generation of neutrophils correlate with their partition coefficients. Anesthesia Analgesia. 1997;84:405–412
  9. Howell TH, Williams RC. Nonsteroidal anti-inflammatory drugs as inhibitors of periodontal disease progression. Critical Reviews in Oral Biology & Medicine. 1993;4:177–196
  10. da Costa JC, Olsen PC, de Azeredo Siqueira R, de Frias Carvalho V, Serra MF, Alves LA, et al. JMF2-1, a lidocaine derivative acting on airways spasm and lung allergic inflammation in rats. Journal of Allergy and Clinical Immunology. 2007;119(1):219–225
  11. Huang TK, Uyehara CF, Balaraman V, Miyasato CY, Person D, Egan E, et al. Surfactant lavage with lidocaine improves pulmonary function in piglets after HCl-induced acute lung injury. Lung. 2004;182:15–25
  12. Nishina K, Mikawa K, Maekawa N, Takao Y, Obara H. Does early posttreatment with lidocaine attenuate endotoxin-induced acute injury in rabbits?. Anesthesiology. 1995;83:169–177
  13. Nishina K, Mikawa K, Takao Y, Shiga M, Maekawa N, Obara H. Intravenous lidocaine attenuates acute lung injury induced by hydrochloric acid aspiration in rabbits. Anesthesiology. 1998;88:1300–1309
  14. Mattsson U, Cassuto J, Jontell M, Jonsson A, Sinclair R, Tarnow P. Digital image analysis of erythema development after experimental thermal injury to human skin: effect of postburn topical local anesthetics (EMLA). Anesthesia Analgesia. 1999;88:1131–1136
  15. Gasparoni A, De Amici D, Ciardelli L, Autelli M, Regazzi-Bonora M, Bartoli A, et al. Effect of lidocaine on neutrophil chemotaxis in newborn infants. Journal of Clinical Immunology. 1998;18:210–213
  16. Goto Y, Ho SL, McAdoo J, Fanning NF, Wang J, Redmond HP, et al. General versus regional anaesthesia for cataract surgery: effects on neutrophil apoptosis and the postoperative pro-inflammatory state. European Journal of Anaesthesiology. 2000;17:474–480
  17. Jonsson A, Cassuto J, Tarnow P, Sinclair R, Bennett A, Tavares IA. Effects of amide local anaesthetics on eicosanoid formation in burned skin. Acta Anaesthesiologica Scandinavica. 1999;43:618–622
  18. Yregard L, Cassuto J, Tarnow P, Nilsson U. Influence of local anaesthetics on inflammatory activity postburn. Burns. 2003;29:335–341
  19. Hunt LW, Frigas E, Butterfield JH, Kita H, Blomgren J, Dunnette SL, et al. Treatment of asthma with nebulized lidocaine: a randomized, placebo-controlled study. Journal of Allergy and Clinical Immunology. 2004;113:853–859

PII: S0300-5712(08)00282-0

doi: 10.1016/j.jdent.2008.10.005

Journal of Dentistry
Volume 37, Issue 2 , Pages 93-97 , February 2009

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