Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation

Sterer, Nir; Nuas, Shada; Mizrahi, Boaz; Goldenberg, Chen; Weiss, Ervin I.; Domb, Abraham; Davidi, Michael Perez

doi:10.1016/j.jdent.2008.04.001

« Previous Next »Journal of Dentistry
Volume 36, Issue 7 , Pages 535-539, July 2008

Oral malodor reduction by a palatal mucoadhesive tablet containing herbal formulation

Nir Sterer
- Department of Prosthodontics, Faculty of Dentistry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
- Corresponding author at: Department of Prosthodontics, Hebrew University-Hadassah School of Dental Medicine, P.O. Box 12272, Jerusalem 91120, Israel. Tel.: +972 2 6776142; fax: +972 2 6429683.
Shada Nuas
- Department of Prosthodontics, Faculty of Dentistry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Boaz Mizrahi
- Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel
Chen Goldenberg
- Department of Prosthodontics, Faculty of Dentistry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Ervin I. Weiss
- Department of Prosthodontics, Faculty of Dentistry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
Abraham Domb
- Department of Medicinal Chemistry and Natural Products, School of Pharmacy, Faculty of Medicine, The Hebrew University, Jerusalem, Israel
Michael Perez Davidi
- Department of Prosthodontics, Faculty of Dentistry, Hadassah-Hebrew University Medical Center, Jerusalem, Israel

Received 16 January 2008; received in revised form 31 March 2008; accepted 1 April 2008.

Abstract

Objective

The aim of the present study was to test the effect of a palatal mucoadhesive tablet containing an herbal formulation on oral malodor production and volatile sulfide compound (VSC) levels, and to evaluate its antimicrobial activity.

Methods

A total of 56 healthy young volunteers participated in experiments 1 and 2. The palatal adhesive tablets were prepared with different active ingredients (herbal formulation, zinc and chlorhexidine), or without an active ingredient as control (placebo). Measurement included odor judge scores (two judges) and VSC readings by a sulfide monitor (Halimeter^®). In experiment 3, the antimicrobial activity of the herbal formulation ingredients (i.e. sage, Echinacea, Lavender and Mastic gum) were tested against three oral pathogens (Streptoccocus mutans, Porphyromonas gingivalis and Candida albicans) by the agar diffusion test.

Results

Application of the palatal adhesive tablets containing herbal formulation resulted in a significant reduction in both oral malodor scores (p<0.001) and VSC levels (p=0.013). Herbal formulation showed higher significance in VSC reduction (p=0.001), as compared to zinc and chlorhexidine (p=0.024 and 0.032, respectively). Sage, Lavender and Mastic gum showed antimicrobial activity against all three oral pathogens.

Conclusions

Results of the present study suggest that the palatal adhesive tablets containing herbal formulation may serve as an effective means of treatment for patients complaining of oral malodor.

Keywords: Halitosis, Oral malodor treatment, Natural medicinals, Sustained release