Journal of Dentistry
Volume 36, Issue 6 , Pages 379-386 , June 2008

A paradigm shift in endodontic management of immature teeth: Conservation of stem cells for regeneration

Received 11 January 2008 ,Revised 4 March 2008 ,Accepted 4 March 2008.

References 

  1. NIH. Regenerative medicine. National Institute of Health Fact Sheet 2006; www.nih.gov/about/researchresultsforthepublic/Regen.pdf.
  2. Mason C, Dunnill P. A brief definition of regenerative medicine. Regenerative Medicine. 2008;3:1–5
  3. Daar AS, Greenwood HL. A proposed definition of regenerative medicine. Journal of Tissue Engineering and Regenerative Medicine. 2007;1:179–184
  4. Murray PE, Garcia-Godoy F, Hargreaves KM. Regenerative endodontics: a review of current status and a call for action. Journal of Endodontics. 2007;33:377–390
  5. Robey PG, Bianco P. The use of adult stem cells in rebuilding the human face. Journal of the American Dental Association. 2006;137:961–972
  6. Gronthos S, Mankani M, Brahim J, Robey PG, Shi S. Postnatal human dental pulp stem cells (DPSCs) in vitro and in vivo. Proceedings of the National Academy of Sciences. 2000;97:13625–13630
  7. Miura M, Gronthos S, Zhao M, Lu B, Fisher LW, Robey PG, et al. SHED: stem cells from human exfoliated deciduous teeth. Proceedings of the National Academy of Sciences. 2003;100:5807–5812
  8. Sonoyama W, Liu Y, Fang D, Yamaza T, Seo BM, Zhang C, et al. Mesenchymal stem cell-mediated functional tooth regeneration in Swine. PLoS ONE. 2006;1:e79
  9. Sonoyama W, Liu Y, Yamaza T, Tuan RS, Wang S, Shi S, et al. Characterization of the apical papilla and its residing stem cells from human immature permanent teeth: a pilot study. Journal of Endodontics. 2008;34:166–171
  10. Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, et al. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004;364:149–155
  11. Gronthos S, Brahim J, Li W, Fisher LW, Cherman N, Boyde A, et al. Stem cell properties of human dental pulp stem cells. Journal of Dental Research. 2002;81:531–535
  12. Zhang W, Walboomers XF, Shi S, Fan M, Jansen JA. Multilineage differentiation potential of stem cells derived from human dental pulp after cryopreservation. Tissue Engineering. 2006;12:2813–2823
  13. d’Aquino R, Graziano A, Sampaolesi M, Laino G, Pirozzi G, De Rosa A, et al. Human postnatal dental pulp cells co-differentiate into osteoblasts and endotheliocytes: a pivotal synergy leading to adult bone tissue formation. Cell Death & Differentiation. 2007;
  14. Laino G, d’Aquino R, Graziano A, Lanza V, Carinci F, Naro F, et al. A new population of human adult dental pulp stem cells: a useful source of living autologous fibrous bone tissue (LAB). Journal of Bone and Mineral Research. 2005;20:1394–1402
  15. Laino G, Carinci F, Graziano A, d’Aquino R, Lanza V, De Rosa A, et al. In vitro bone production using stem cells derived from human dental pulp. Journal of Craniofacial Surgery. 2006;17:511–515
  16. Huang G, Sonoyama W, Chen J, Park S. In vitro characterization of human dental pulp cells: various isolation methods and culturing environments. Cell and Tissue Research. 2006;324:225–236
  17. Ivanovski S, Gronthos S, Shi S, Bartold PM. Stem cells in the periodontal ligament. Oral Diseases. 2006;12:358–363
  18. Nakashima M, Akamine A. The application of tissue engineering to regeneration of pulp and dentin in endodontics. Journal of Endodontics. 2005;31:711–718
  19. Chueh L-H, Huang GTJ. Immature teeth with periradicular periodontitis or abscess undergoing apexogenesis: a paradigm shift. Journal of Endodontics. 2006;32:1205–1213
  20. Rafter M. Apexification: a review. Dental Traumatology. 2005;21:1–8
  21. Bishop BG, Woollard GW. Modern endodontic therapy for an incompletely developed tooth. General Dentistry. 2002;50:252–256
  22. Goldstein S, Sedaghat-Zandi A, Greenberg M, Friedman S. Apexification & apexogenesis. The New York State Dental Journal. 1999;65:23–25
  23. Webber RT. Apexogenesis versus apexification. Dental Clinics of North America. 1984;28:669–697
  24. Iwaya SI, Ikawa M, Kubota M. Revascularization of an immature permanent tooth with apical periodontitis and sinus tract. Dental Traumatology. 2001;17:185–187
  25. Banchs F, Trope M. Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol?. Journal of Endodontics. 2004;30:196–200
  26. Thibodeau B, Trope M. Pulp revascularization of a necrotic infected immature permanent tooth: case report and review of the literature. Pediatric Dentistry. 2007;29:47–50
  27. Rafter M. Vital pulp therapy—a review. Journal of the Irish Dental Association. 2001;47:115–121
  28. Weisleder R, Benitez CR. Maturogenesis: is it a new concept?. Journal of Endodontics. 2003;29:776–778
  29. Rule DC, Winter GB. Root growth and apical repair subsequent to pulpal necrosis in children. British Dental Journal. 1966;120:586–590
  30. Matusow RJ. Acute pulpal-alveolar cellulitis syndrome V. Apical closure of immature teeth by infection control: case report and a possible microbial-immunologic etiology, Part 1. Oral Surgery Oral Medicine & Oral Pathology. 1991;71:737–742
  31. Matusow RJ. Acute pulpal-alveolar cellulitis syndrome V. Apical closure of immature teeth by infection control: the importance of an endodontic seal with therapeutic factors, Part 2. Oral Surgery Oral Medicine & Oral Pathology. 1991;72:96–100
  32. Saad AY. Calcium hydroxide and apexogenesis. Oral Surgery Oral Medicine & Oral Pathology. 1988;66:499–501
  33. Whittle M. Apexification of an infected untreated immature tooth. Journal of Endodontics. 2000;26:245–247
  34. Selden HS. Apexification: an interesting case. Journal of Endodontics. 2002;28:44–45
  35. Sato I, Ando-Kurihara N, Kota K, Iwaku M, Hoshino E. Sterilization of infected root-canal dentine by topical application of a mixture of ciprofloxacin, metronidazole and minocycline in situ. International Endodontic Journal. 1996;29:118–124
  36. Hoshino E, Kurihara-Ando N, Sato I, Uematsu H, Sato M, Kota K, et al. In-vitro antibacterial susceptibility of bacteria taken from infected root dentine to a mixture of ciprofloxacin, metronidazole and minocycline. International Endodontic Journal. 1996;29:125–130
  37. Thibodeau B, Teixeira F, Yamauchi M, Caplan DJ, Trope M. Pulp revascularization of immature dog teeth with apical periodontitis. Journal of Endodontics. 2007;33:680–689
  38. Cooke C, Rowbotham TC. The closure of open apices in non-vital immature incisor teeth. British Dental Journal. 1988;165:420–421
  39. Windley W, Teixeira F, Levin L, Sigurdsson A, Trope M. Disinfection of immature teeth with a triple antibiotic paste. Journal of Endodontics. 2005;31:439–443
  40. Kim ST, Abbott PV, McGinley P. The effects of Ledermix paste on discolouration of immature teeth. International Endodontic Journal. 2000;33:233–237
  41. Kim ST, Abbott PV, McGinley P. The effects of Ledermix paste on discolouration of mature teeth. International Endodontic Journal. 2000;33:227–232
  42. Ostby BN. The role of the blood clot in endodontic therapy. An experimental histologic study. Acta Odontologica Scandinavica. 1961;19:324–353
  43. Myers WC, Fountain SB. Dental pulp regeneration aided by blood and blood substitutes after experimentally induced periapical infection. Oral Surgery Oral Medicine & Oral Pathology. 1974;37:441–450
  44. Cox CF, Tarim B, Kopel H, Gurel G, Hafez A. Technique sensitivity: biological factors contributing to clinical success with various restorative materials. Advances in Dental Research. 2001;15:85–90
  45. Farsi N, Alamoudi N, Balto K, Al Mushayt A. Clinical assessment of mineral trioxide aggregate (MTA) as direct pulp capping in young permanent teeth. The Journal of Clinical Pediatric Dentistry. 2006;31:72–76
  46. Al-Hiyasat AS, Barrieshi-Nusair KM, Al-Omari MA. The radiographic outcomes of direct pulp-capping procedures performed by dental students: a retrospective study. Journal of American Dental Association. 2006;137:1699–1705
  47. Katebzadeh N, Dalton BC, Trope M. Strengthening immature teeth during and after apexification. Journal of Endodontics. 1998;24:256–259
  48. Nevins A, Finkelstein F, Laporta R, Borden BG. Induction of hard tissue into pulpless open-apex teeth using collagen–calcium phosphate gel. Journal of Endodontics. 1978;4:76–81
  49. Nevins A, Wrobel W, Valachovic R, Finkelstein F. Hard tissue induction into pulpless open-apex teeth using collagen–calcium phosphate gel. Journal of Endodontics. 1977;3:431–433

PII: S0300-5712(08)00078-X

doi: 10.1016/j.jdent.2008.03.002

Journal of Dentistry
Volume 36, Issue 6 , Pages 379-386 , June 2008