Journal of Dentistry
Volume 36, Issue 2 , Pages 104-116, February 2008

The application of ozone in dentistry: A systematic review of literature

  • Amir Azarpazhooh

      Affiliations

    • Department of Endodontics and Community Dental Health Services Research Unit, Faculty of Dentistry, University of Toronto, Room #521A, 124 Edward Street, Toronto, ON, M5G 1G6 Canada
    • Corresponding Author InformationCorresponding author. Tel.: +1 416 979 4907x4429; fax: +1 416 979 4936.
    • ,
  • Hardy Limeback

      Affiliations

    • Department of Preventive Dentistry, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON, M5G 1G6 Canada

Received 10 May 2007; received in revised form 9 November 2007; accepted 18 November 2007.

Abstract 

Objectives

(1) To systematically review the clinical application and remineralization potentials of ozone in dentistry; (2) To summarize the available in vitro applications of ozone in dentistry.

Sources

Ovid MEDLINE, CINAHL, etc. (up to April 2007).

Study selection

In vitro or in vivo English language publications, original studies, and reviews were included. Conference papers, abstracts, and posters were excluded.

Results

In vitro:

•Good evidence of ozone biocompatibility with human oral epithelial cells, gingival fibroblast, and periodontal cells;

•Conflicting evidence of antimicrobial efficacy of ozone but some evidence that ozone is effective in removing the microorganisms from dental unit water lines, the oral cavity, and dentures;

•Conflicting evidence for the application of ozone in endodontics;

•Insufficient evidence for the application of ozone in oral surgery and implantology;

•Good evidence of the prophylactic application of ozone in restorative dentistry prior to etching and the placement of dental sealants and restorations.

In vivo: Despite the promising in vitro evidence, the clinical application of ozone in dentistry (so far in management of dental and root caries) has not achieved a strong level of efficacy and cost-effectiveness.

Conclusions

While laboratory studies suggest a promising potential of ozone in dentistry, this has not been fully realised in clinical studies to date. More well designed and conducted double-blind randomised clinical trials with adequate sample size, limited or no loss to follow up, and carefully standardised methods of measurement and analyses are needed to evaluate the possible use of ozone as a treatment modality in dentistry.

Keywords: Ozone, Prevention, Treatment, Dentistry, Systematic review

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PII: S0300-5712(07)00241-2

doi:10.1016/j.jdent.2007.11.008

Journal of Dentistry
Volume 36, Issue 2 , Pages 104-116, February 2008

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