Journal of Dentistry
Volume 36, Issue 2 , Pages 95-103 , February 2008

Bacterial resistance and the dental professionals’ role to halt the problem

  • Mohammed Al-Haroni

      Affiliations

    • Corresponding Author InformationCorrespondence address: Laboratory of Oral Microbiology, Armauer Hansens Hus, N-5021, Bergen, Norway. Tel.: +47 55 97 5784; fax: +47 55 97 4979.

Received 26 September 2007 ,Revised 12 November 2007 ,Accepted 16 November 2007.

References 

  1. Falagas ME, Bliziotis IA. Pandrug-resistant Gram-negative bacteria: the dawn of the post-antibiotic era?. International Journal of Antimicrobial Agents. 2007;29:630–636
  2. WHO report on infectious diseases. Weekly Epidemiological Record 1999;74:279.
  3. Wise R, Hart T, Cars O, Streulens M, Helmuth R, Huovinen P, et al. Antimicrobial resistance. Is a major threat to public health. BMJ. 1998;317:609–610
  4. Sweeney LC, Dave J, Chambers PA, Heritage J. Antibiotic resistance in general dental practice—a cause for concern?. The Journal of Antimicrobial Chemotherapy. 2004;53:567–576
  5. Andersson D. The ways in which bacteria resist antibiotics (background document). In: Seminar on the Global Threat of Antibiotic Resistance – Exploring Roads Towards Concerted Action. 2004;
  6. Bebear CM, Pereyre S. Mechanisms of drug resistance in Mycoplasma pneumoniae. Current Drug Targets – Infectious Disorders. 2005;5:263–271
  7. Pavicic MJ, van Winkelhoff AJ, Pavivic-Temming YA, de Graaff J. Metronidazole susceptibility factors in Actinobacillus actinomycetemcomitans. The Journal of Antimicrobial Chemotherapy. 1995;35:263–269
  8. Narikawa S. Distribution of metronidazole susceptibility factors in obligate anaerobes. The Journal of Antimicrobial Chemotherapy. 1986;18:565–574
  9. Jain R, Rivera MC, Moore JE, Lake JA. Horizontal gene transfer in microbial genome evolution. Theoretical Population Biology. 2002;61:489–495
  10. Griffith F. The significance of pneumococcal types. Journal of Hygiene. 1928;27:113–159
  11. Cvitkovitch DG. Genetic competence and transformation in oral streptococci. Critical Reviews in Oral Biology & Medicine. 2001;12:217–243
  12. Hakenbeck R, Coyette J. Resistant penicillin-binding proteins. Cellular and Molecular Life Sciences. 1998;54:332–340
  13. Lysogeny Lwoff A. Bacteriological Reviews. 1953;17:269–337
  14. Hewitt LF. Bacteriophage as a factor in epidemiology and bacterial evolution; lysis of diphtheria Bacilli by Staphylococcal bacteriophage. The Lancet. 1952;2:272–273
  15. Freeman VJ, Morse IU. Further observations on the change to virulence of bacteriophage-infected a virulent strains of Corynebacterium diphtheria. Journal of Bacteriology. 1952;63:407–414
  16. Tatum EL, Lederberg J. Gene Recombination in the Bacterium Escherichia coli. Journal of Bacteriology. 1947;53:673–684
  17. Moritz EM, Hergenrother PJ. The prevalence of plasmids and other mobile genetic elements in clinically important drug-resistant bacteria. In:  Amabile-Cuevas CF editors. Antimicrobial resistance in bacteria. Wymondham, UK: Horizon Bioscience; 2007;p. 25–53
  18. Dowson CG, Hutchison A, Woodford N, Johnson AP, George RC, Spratt BG. Penicillin-resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae. In: Proceedings of the National Academy of Sciences of the United States of America, 87. 1990;p. 5858–5862
  19. Livermore DM. beta-Lactamases in laboratory and clinical resistance. Clinical Microbiology Reviews. 1995;8:557–584
  20. Carlier JP, Sellier N, Rager MN, Reysset G. Metabolism of a 5-nitroimidazole in susceptible and resistant isogenic strains of Bacteroides fragilis. Antimicrobial Agents and Chemotherapy. 1997;41:1495–1499
  21. Leclercq R, Courvalin P. Intrinsic and unusual resistance to macrolide, lincosamide, and streptogramin antibiotics in bacteria. Antimicrobial Agents and Chemotherapy. 1991;35:1273–1276
  22. Leclercq R, Courvalin P. Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification. Antimicrobial Agents and Chemotherapy. 1991;35:1267–1272
  23. Connell SR, Tracz DM, Nierhaus KH, Taylor DE. Ribosomal protection proteins and their mechanism of tetracycline resistance. Antimicrobial Agents and Chemotherapy. 2003;47:3675–3681
  24. Roberts MC. Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution. FEMS Microbiology Reviews. 1996;19:1–24
  25. Bush K. Classification of beta-lactamases: groups 1, 2a, 2b, and 2b′. Antimicrobial Agents and Chemotherapy. 1989;33:264–270
  26. Bush K. Classification of beta-lactamases: groups 2c, 2d, 2e, 3, and 4. Antimicrobial Agents and Chemotherapy. 1989;33:271–276
  27. Bush K, Jacoby GA, Medeiros AA. A functional classification scheme for beta-lactamases and its correlation with molecular structure. Antimicrobial Agents and Chemotherapy. 1995;39:1211–1233
  28. Ambler RP. The structure of beta-lactamases. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 1980;289:321–31.
  29. Pitout JD, Sanders CC, Sanders WE. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. The American Journal of Medicine. 1997;103:51–59
  30. Handal T, Olsen I. Antimicrobial resistance with focus on oral beta-lactamases. European Journal of Oral Sciences. 2000;108:163–174
  31. Walker CB, Gordon JM, Socransky SS. Antibiotic susceptibility testing of subgingival plaque samples. Journal of Clinical Periodontology. 1983;10:422–432
  32. Sutter VL, Jones MJ, Ghoneim AT. Antimicrobial susceptibilities of bacteria associated with periodontal disease. Antimicrobial Agents and Chemotherapy. 1983;23:483–486
  33. Valdes MV, Lobbins PM, Slots J. Beta-lactamase producing bacteria in the human oral cavity. Journal of Oral Pathology. 1982;11:58–63
  34. Heimdahl A, von Konow L, Nord CE. Isolation of beta-lactamase-producing Bacteroides strains associated with clinical failures with penicillin treatment of human orofacial infections. Archives of Oral Biology. 1980;25:689–692
  35. Kinder SA, Holt SC, Korman KS. Penicillin resistance in the subgingival microbiota associated with adult periodontitis. Journal of Clinical Microbiology. 1986;23:1127–1133
  36. Legg JA, Wilson M. The prevalence of beta-lactamase producing bacteria in subgingival plaque and their sensitivity to Augmentin. British Journal of Oral & Maxillofacial Surgery. 1990;28:180–184
  37. Fosse T, Madinier I, Hitzig C, Charbit Y. Prevalence of beta-lactamase-producing strains among 149 anaerobic gram-negative rods isolated from periodontal pockets. Oral Microbiology and Immunology. 1999;14:352–357
  38. Nyfors S, Kononen E, Takala A, Jousimies-Somer H. Beta-lactamase production by oral anaerobic gram-negative species in infants in relation to previous antimicrobial therapy. Antimicrobial Agents and Chemotherapy. 1999;43:1591–1594
  39. Kononen E, Nyfors S, Matto J, Asikainen S, Jousimies-Somer H. beta-lactamase production by oral pigmented Prevotella species isolated from young children. Clinical Infectious Diseases. 1997;25:S272–S274
  40. Tuner K, Lindqvist L, Nord CE. Purification and properties of a novel beta-lactamase from Fusobacterium nucleatum. Antimicrobial Agents and Chemotherapy. 1985;27:943–947
  41. Kononen E, Kanervo A, Salminen K, Jousimies-Somer H. beta-lactamase production and antimicrobial susceptibility of oral heterogeneous Fusobacterium nucleatum populations in young children. Antimicrobial Agents and Chemotherapy. 1999;43:1270–1273
  42. van Winkelhoff AJ, Herrera Gonzales D, Winkel EG, Dellemijn-Kippuw N, Vandenbroucke-Grauls CM, Sanz M. Antimicrobial resistance in the subgingival microflora in patients with adult periodontitis. A comparison between The Netherlands and Spain. Journal of Clinical Periodontology. 2000;27:79–86
  43. Walker CB. The acquisition of antibiotic resistance in the periodontal microflora. Periodontology 2000. 1996;10:79–88
  44. van Winkelhoff AJ, Winkel EG, Barendregt D, Dellemijn-Kippuw N, Stijne A, van der Velden U. beta-Lactamase producing bacteria in adult periodontitis. Journal of Clinical Periodontology. 1997;24:538–543
  45. Nagy E, Szoke I, Gacs M, Csiszar K. Resistance to beta-lactam antibiotics and beta-lactamase production of Bacteroides, Porphyromonas and Prevotella strains. Acta Microbiologica et Immunologica Hungarica. 1995;42:287–299
  46. Prieto-Prieto J, Calvo A. Microbiological basis of oral infections and sensitivity to antibiotics. Medicina Oral, Patología Oral y Cirugía Bucal. 2004;9:15–8; 1–4
  47. Lacroix JM, Walker C. Characterization of a beta-lactamase found in Eikenella corrodens. Antimicrobial Agents and Chemotherapy. 1991;35:886–891
  48. Lacroix JM, Walker CB. Identification of a streptomycin resistance gene and a partial Tn3 transposon coding for a beta-lactamase in a periodontal strain of Eikenella corrodens. Antimicrobial Agents and Chemotherapy. 1992;36:740–743
  49. Giraud-Morin C, Madinier I, Fosse T. Sequence analysis of cfxA2-like beta-lactamases in Prevotella species. The Journal of Antimicrobial Chemotherapy. 2003;51:1293–1296
  50. Madinier IM, Fosse TB, Hitzig C, Charbit Y, Hannoun LR. Resistance profile survey of 50 periodontal strains of Actinobacillus actinomyectomcomitans. Journal of Periodontology. 1999;70:888–892
  51. Handal T, Olsen I, Walker CB, Caugant DA. Beta-lactamase production and antimicrobial susceptibility of subgingival bacteria from refractory periodontitis. Oral Microbiology and Immunology. 2004;19:303–308
  52. Handal T, Olsen I, Walker CB, Caugant DA. Detection and characterization of beta-lactamase genes in subgingival bacteria from patients with refractory periodontitis. FEMS Microbiology Letters. 2005;242:319–324
  53. Al-Haroni M, Skaug N, Bakken V, Cash P. Proteomic analysis of Ampicillin-resistant oral Fusobacterium nucleatum. Oral Microbiology And Immunology. 2008;23:36–42
  54. Levy SB, Marshall B. Antibacterial resistance worldwide: causes, challenges and responses. Nature Medicine. 2004;10:S122–S129
  55. Bonten MJ, Slaughter S, Ambergen AW, Hayden MK, van Voorhis J, Nathan C, et al. The role of “colonization pressure” in the spread of vancomycin-resistant enterococci: an important infection control variable. Archives of Internal Medicine. 1998;158:1127–1132
  56. Harbarth S, Samore MH. Antimicrobial resistance determinants and future control. Emerging Infectious Diseases. 2005;11:794–801
  57. Goossens H, Ferech M, Vander Stichele R, Elseviers M. Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. The Lancet. 2005;365:579–587
  58. Austin DJ, Anderson RM. Studies of antibiotic resistance within the patient, hospitals and the community using simple mathematical models. Philosophical Transactions of the Royal Society of London. Series B, Biological sciences 1999;354:721–38.
  59. Seppala H, Klaukka T, Vuopio-Varkila J, Muotiala A, Helenius H, Lager K, et al. The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group A streptococci in Finland. Finnish Study Group for Antimicrobial Resistance. The New England Journal of Medicine. 1997;337:441–446
  60. Montecalvo MA, Jarvis WR, Uman J, Shay DK, Petrullo C, Rodney K, et al. Infection-control measures reduce transmission of vancomycin-resistant enterococci in an endemic setting. Annals of Internal Medicine. 1999;131:269–272
  61. Nourse C, Byrne C, Murphy H, Kaufmann ME, Clarke A, Butler K. Eradication of vancomycin resistant Enterococcus faecium from a paediatric oncology unit and prevalence of colonization in hospitalized and community-based children. Epidemiology and Infection. 2000;124:53–59
  62. Courvalin P. Antimicrobial drug resistance: “Prediction Is Very Difficult, Especially about the Future”. Emerging Infectious Diseases. 2005;11:1503–1506
  63. Canet JJ, Garau J. Importance of dose and duration of beta-lactam therapy in nasopharyngeal colonization with resistant pneumococci. The Journal of Antimicrobial Chemotherapy. 2002;50:39–43
  64. Larrabee T. Prescribing practices that promote antibiotic resistance: strategies for change. Journal of Pediatric Nursing. 2002;17:126–132
  65. Cornaglia G, Lonnroth A, Struelens M. Report from the European Conference on the Role of Research in Combating Antibiotic Resistance, 2003. Clinical Microbiology and Infection. 2004;10:473–497
  66. Macfarlane J, Holmes W, Macfarlane R, Britten N. Influence of patients’ expectations on antibiotic management of acute lower respiratory tract illness in general practice: questionnaire study. BMJ. 1997;315:1211–1214
  67. Buke C, Hosgor-Limoncu M, Ermertcan S, Ciceklioglu M, Tuncel M, Kose T, et al. Irrational use of antibiotics among university students. The Journal of Infection. 2005;51:135–139
  68. Okeke IN, Klugman KP, Bhutta ZA, Duse AG, Jenkins P, O’Brien TF, et al. Antimicrobial resistance in developing countries. Part II: strategies for containment. The Lancet Infectious Diseases. 2005;5:568–580
  69. Okeke IN, Laxminarayan R, Bhutta ZA, Duse AG, Jenkins P, O’Brien TF, et al. Antimicrobial resistance in developing countries. Part I: recent trends and current status. The Lancet Infectious Diseases. 2005;5:481–493
  70. Okeke IN, Lamikanra A, Edelman R. Socioeconomic and behavioral factors leading to acquired bacterial resistance to antibiotics in developing countries. Emerging Infectious Diseases. 1999;5:18–27
  71. Palmer NO, Martin MV, Pealing R, Ireland RS. An analysis of antibiotic prescriptions from general dental practitioners in England. The Journal of Antimicrobial Chemotherapy. 2000;46:1033–1035
  72. Standing Medical Advisory Committee . The path of least resistance. London: Department of Health; 1998;
  73. Pallasch TJ. Antibiotic resistance. Dental Clinics of North America. 2003;47:623–639
  74. Al-Haroni M, Skaug N. Incidence of antibiotic prescribing in dental practice in Norway and its contribution to national consumption. The Journal of Antimicrobial Chemotherapy. 2007;59:1161–1166
  75. Epstein JB, Chong S, Le ND. A survey of antibiotic use in dentistry. Journal of the American Dental Association. 2000;131:1600–1609
  76. Andersson DI. The biological cost of mutational antibiotic resistance: any practical conclusions?. Current Opinion in Microbiology. 2006;9:461–465
  77. Horcajada JP, Soto S, Gajewski A, Smithson A, Jimenez de Anta MT, Mensa J, et al. Quinolone-resistant uropathogenic Escherichia coli strains from phylogenetic group B2 have fewer virulence factors than their susceptible counterparts. Journal of Clinical Microbiology. 2005;43:2962–2964
  78. Vila J, Simon K, Ruiz J, Horcajada JP, Velasco M, Barranco M, et al. Are quinolone-resistant uropathogenic Escherichia coli less virulent?. The Journal of Infectious Diseases. 2002;186:1039–1042
  79. Feres M, Haffajee AD, Allard K, Som S, Goodson JM, Socransky SS. Antibiotic resistance of subgingival species during and after antibiotic therapy. Journal of Clinical Periodontology. 2002;29:724–735
  80. Andersson DI. Persistence of antibiotic resistant bacteria. Current Opinion in Microbiology. 2003;6:452–456
  81. Nilsson AI, Zorzet A, Kanth A, Dahlstrom S, Berg OG, Andersson DI. Reducing the fitness cost of antibiotic resistance by amplification of initiator tRNA genes. In: Proceedings of the National Academy of Sciences of the United States of America, 103. 2006;p. 6976–6981
  82. Cars O, Molstad S, Melander A. Variation in antibiotic use in the European Union. The Lancet. 2001;357:1851–1853
  83. Theilade E, Theilade J. Role of plaque in the etiology of periodontal disease and caries. Oral Sciences Reviews. 1976;9:23–63
  84. Sbordone L, Bortolaia C. Oral microbial biofilms and plaque-related diseases: microbial communities and their role in the shift from oral health to disease. Clinical Oral Investigations. 2003;7:181–188
  85. Slots J, Ting M. Systemic antibiotics in the treatment of periodontal disease. Periodontology 2000. 2002;28:106–176
  86. Longman LP, Martin MV. A practical guide to antibiotic prophylaxis in restorative dentistry. Dental Update. 1999;26:7–14
  87. Palmer NA. Revisiting the role of dentists in prescribing antibiotics. Dental Update. 2003;30:570–574
  88. Samaranayake LP. Antimicrobial chemotherapy. Essential microbiology for dentistry. Philadelphia, PA: Churchill Livingstone Elsevier; 2006;p. 67–76
  89. Seymour RA, Whitworth JM. Antibiotic prophylaxis for endocarditis, prosthetic joints, and surgery. Dental Clinics of North America. 2002;46:635–651
  90. Tong DC, Rothwell BR. Antibiotic prophylaxis in dentistry: a review and practice recommendations. Journal of the American Dental Association. 2000;131:366–374
  91. Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, et al. Prevention of infective endocarditis: guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Cardiovascular Disease in the Young, and the Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Care and Outcomes Research Interdisciplinary Working Group. Journal of the American Dental Association. 2007;138:739–45, 47–60
  92. Prophylaxis against infective endocarditis guideline: consultation. The National Institute for Health and Clinical Excellence (NICE). http://www.nice.org.uk/guidance/index.jsp?action=folder&o=38144 [12 November 2007, date last accessed].
  93. Krigar DM, Kaltschmitt J, Krieger JK, Eickholz P. Two subgingival plaque-sampling strategies used with RNA probes. J Periodontol. 2007;78:72–78
  94. Horiba N, Yoshida T, Suzuki K, Maekawa Y, Ito M, Matsumoto T, et al. Isolation of methicillin-resistant staphylococci in the dental operatory. Journal of Endodontics. 1995;21:21–25
  95. Kurita H, Kurashina K, Honda T. Nosocomial transmission of methicillin-resistant Staphylococcus aureus via the surfaces of the dental operatory. British Dental Journal. 2006;201:297–300; discussion 291
  96. Rautemaa R, Nordberg A, Wuolijoki-Saaristo K, Meurman JH. Bacterial aerosols in dental practice—a potential hospital infection problem?. The Journal of Hospital Infection. 2006;64:76–81

PII: S0300-5712(07)00240-0

doi: 10.1016/j.jdent.2007.11.007

Journal of Dentistry
Volume 36, Issue 2 , Pages 95-103 , February 2008

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