Journal of Dentistry
Volume 35, Issue 1 , Pages 2-20 , January 2007

What is the evidence for paediatric dental sedation?

  • L.L. Matharu

      Affiliations

    • Unit of Paediatric Dentistry, King's College London, Dental Institute Bessemer Road, London SE5 9RW, United Kingdom
    • Corresponding Author InformationCorresponding author. Tel.: +44 20 7737 4000x2417.
  • ,
  • P.F. Ashley

      Affiliations

    • Unit of Paediatric Dentistry, UCL Eastman Dental Institute, 256 Gray's Inn Road, London WC1X 8LD, United Kingdom

Received 7 June 2006 ,Accepted 8 August 2006.

References 

  1. National Centre for Health Statistics (NCHS). Third national health and nutrition examination survey (NHANES III) reference manuals and reports [CD-ROM]. Hyattsville, MD: NCHS, US Department of Health and Human Services, Public Health Services, Centers for Disease Control and Prevention; 1996.
  2. Pitts NB, Evans DJ, Nugent ZJ. The dental caries experience of 5-year-old children in the United Kingdom. Surveys coordinated by the British Association for the Study of Community Dentistry in 1999/2000. Community Dental Health. 2001;18:49–55
  3. American Academy of Pediatrics Committee on Drugs . Guidelines for monitoring and management of pediatric patients during and after sedation for diagnostic and therapeutic procedures. Pediatrics. 1992;6:1110–1115
  4. Matharu L, Ashley P. Sedation of anxious children undergoing dental treatment. Cochrane Library. 2006;(1):
  5. Lindsay SJ, Yates JA. The effectiveness of oral diazepam in anxious child dental patients. British Dental Journal. 1985;159(5):149–153
  6. Veerkamp JSJ, Porcelijn T, Gruythuysen RJ. Intravenous sedation for outpatient treatment of child dental patients: an exploratory study. ASDC Journal of Dentistry for Children. 1997;64(1):48–54
  7. Lima ARA, Costa LRRS, Costa PSS. A randomized controlled crossover trial of oral midazolam and hydroxyzine for pediatric dental sedation. Pesqui Odontol Bras. 2003;17(3):206–211
  8. Lindsay SJ, Roberts GJ. Methods for behaviour research on dentally anxious children. British Dental Journal. 1980;149(6):175–179
  9. Myers GR, Maestrello CL, Mourino AP, Best AM. Effect of submucosal midazolam on behaviour and physiologic response when combined with oral chloral hydrate and nitrous oxide sedation. Pediatric Dentistry. 2003;26(1):37–43
  10. Pisalchaiyong T, Trairatvorakul C, Jirakijja J, Yuktarnonda W. Comparison of the effectiveness of oral diazepam and midazolam for the sedation of autistic patients during dental treatment. Pediatric Dentistry. 2005;27:198–206
  11. Poorman TL, Farrington FH, Mourino AP. Comparison of a chloral hydrate/hydroxine combination with and without meperidine in the sedation of pediatric dental patients. Pediatric Dentistry. 1990;12(5):288–291
  12. Ram D, Mamber E, Chosack A, Fuks AB. The effect of metoclopramide and hydroxyzine in sedation of infants undergoing dental treatment. ASDC Journal of Dentistry for Children. 1999;66(1):49–52
  13. Yanase H, Braham RL, Fukuta O, Kurosu K. A study of the sedative effect of home-administered oral diazepam for the dental treatment of children. International Journal of Paediatric Dentistry. 1996;6(1):13–17
  14. Reeves ST, Wiedenfeld KR, Wrobleski J, Hardin CL, Pinosky ML. A randomized double-blind trial of chloral hydrate/hydroxyzine versus midazolam/acetaminophen in the sedation of pediatric dental outpatients. ASDC Journal of Dentistry for Children. 1996;63(2):95–100
  15. Shapira J, Holan G, Botzer E, Kupieztky A, Tal E, Fuks AB. The effectiveness of midazolam and hydroxyzine as sedative agents for young pediatric dental patients. ASDC Journal of Dentistry for Children. 1996;63(6):421–425
  16. Lam C, Udin RD, Malamed SF, Good DL, Forrest JL. Midazolam premedication in children: a pilot study comparing intramuscular and intranasal administration. Anesthesia Progress. 2005;52:56–61
  17. Lee-Kim SJ, Fadavi S, Punwani I, Koerber A. Nasal versus oral midazolam sedation for pediatric dental patients. Journal of Dentistry for Children. 2004;71:126–130
  18. Meyer M, Mourino AP, Farrington FH. Comparison of triazolam to a chloral hydrate/hydroxyzine combination in the sedation of pediatric dental patients. Pediatric Dentistry. 1990;12(5):283–287
  19. Veerkamp JSJ, Gruythuysen RJM, van Amerongen , Hoogstraten J. Dental treatment of fearful children using nitrous oxide. Part 3. Anxiety during sequential visits. ASDC Journal of Dentistry for Children. 1993;60(3):175–182
  20. Nathan JE, Venham LL, West MS, Werboff J. The effects of nitrous oxide on anxious young pediatric patients across sequential visits: a double blind study. ASDC Journal of Dentistry for Children. 1988;55(3):220–230
  21. Aydintug YS, Okcu KM, Guner Y, Gunaydin Y, Sencimen M. Evaluation of oral or rectal midazolam as conscious sedation for pediatric patients in oral surgery. Military Medicine. 2004;169:270–273
  22. Hartgraves PM, Primosch R. An evaluation of oral and nasal midazolam for pediatric dental sedation. ASDC Journal of Dentistry for Children. 1994;61(3):175–178
  23. Lahoud GY, Averley PA. Comparison of sevoflurane and nitrous oxide mixture with nitrous oxide alone for inhalation conscious sedation in children having dental treatment: a randomised controlled trial. Anaesthesia. 2002;57(5):446–450
  24. Marshall WR, Weaver BD, McCutcheon P. A study of the effectiveness of oral midazolam as a dental pre-operative sedative and hypnotic. Special Care in Dentistry. 1999;19(6):259–266
  25. Moody EH, Mourino AP, Campbell RL. The therapeutic effectiveness of nitrous oxide and chloral hydrate administered orally, rectally, and combined with hydroxyzine for pediatric dentistry. ASDC Journal of Dentistry for Children. 1986;53(6):425–429
  26. Wilson KE, Welbury RR, Girdler NM. A randomised, controlled, crossover trial of oral midazolam and nitrous oxide for paediatric dental sedation. Anaesthesia. 2002;57(9):860–867
  27. Wilson KE, Girdler NM, Welbury RR. Randomized, controlled, cross-over clinical trial comparing intravenous midazolam sedation with nitrous oxide sedation in children undergoing dental extractions. British Journal of Anaesthesia. 2003;91(6):850–856
  28. Averley PA, Lane I, Sykes J, Girdler NM, Steen N, Bond S. An RCT pilot study to test the effects of intravenous midazolam as a conscious sedation technique for anxious children requiring dental treatment—an alternative to general anaesthesia. British Dental Journal. 2004;197(9):553–558
  29. Averley PA, Girdler NM, Bond S, Steen N, Steele J. A randomised controlled trial of paediatric conscious sedation for dental treatment using intravenous midazolam combined with inhaled nitrous oxide or nitrous oxide/sevoflurane. Anaesthesia. 2004;59:844–852
  30. Leelataweewud P, Vann WF, Dilley DC, Lucas WJ. The physiological effects of supplemental oxygen versus nitrous oxide/oxygen during conscious sedation of pediatric dental patients. Pediatric Dentistry. 2000;22(2):125–133
  31. Primosch RE, Buzzi IM, Jerrell G. Effect of nitrous oxide-oxygen inhalation with scavenging on behavioral and physiological parameters during routine pediatric dental treatment. Pediatric Dentistry. 1999;21(7):417–420
  32. Sullivan DC, Wilson CF, Webb MD. A comparison of two oral ketamine–diazepam regimens for the sedation of anxious pediatric dental patients. Pediatric Dentistry. 2001;23(3):223–231
  33. Moore RA, Tramer MR, Carroll D, Wiffen PJ, McQuay HJ. Quantitative systematic review of topically applied non-steroidal anti-inflammatory drugs. BMJ. 1998;316(7128):333–338
  34. Schulz KF, Chalmers I, Hayes RJ, Altman DG. Empirical evidence of bias. Dimensions of methodological quality associated with estimates of treatment effects in controlled trials. JAMA. 1995;273:408–412
  35. Moher D, Schulz KF, Altman DG. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials. Lancet. 2001;357(9263):1191–1194
  36. Evans WO, Tannenbaum K, Turek B, Alling EF. A method for evaluating the use of premedicating agents in difficult pedodontic patients. Journal of Dentistry for Children. 1966;317–323
  37. Flaitz CM, Nowak AJ, Hicks MJ. Double blind comparison of rectally administered diazepam to placebo for pediatric sedation: the cardiovascular response. Anesthesia Progress. 1985;32(6):232–236
  38. Gallardo F, Cornejo G, Auil B. Premedication with flunitrazepam, diazepam and placebo in the apprehensive child. ASDC Journal of Dentistry for Children. 1984;51(3):208–210
  39. Gallardo F, Cornejo G, Borie R. Oral midazolam as premedication for the apprehensive child before dental treatment. Journal of Clinical Paediatric Dentistry. 1994;18(2):123–127
  40. Houpt M, Manetas C, Joshi A, Desjardins P. Effects of chloral hydrate on nitrous oxide sedation of children. Pediatric Dentistry. 1989;11(1):26–29
  41. Kapur A, Chawla HS, Goyal A, Gauba K, Bhardwaj N. Efficacy and acceptability of oral-transmucosal midazolam as a conscious sedation agent in pre-school children. Journal of the Indian Society of Pedodontics and Preventive Dentistry. 2004;22(3):109–113
  42. McKee K, Nazif MM, Jackson DL, Barnhart DC, Close J, Moore PA. Dose–responsive characteristics of meperidine sedation in preschool children. Pediatric Dentistry. 1990;12(4):222–227
  43. Moore PA, Mickey EA, Hargreaves JA, Needleman HL. Sedation in pediatric dentistry: a practical assessment procedure. Journal American Dental Association. 1984;109(4):564–569
  44. Al-Rakaf H, Bello LL, Turkustani A, Adenubi JO. Intranasal midazolam in conscious sedation of young paediatric dental patients. International Journal of Paediatric Dentistry. 2001;11(1):33–40
  45. El Magboul KM, O'Sullivan EA, Curzon ME. A clinical trial comparing two doses of oral temazepam for sedation of paediatric dental patients. International Journal of Paediatric Dentistry. 1995;5(2):97–102
  46. Fuks AB, Kaufman E, Ram D, Hovav S, Shapira J. Assessment of two doses of intranasal midazolam for sedation of young pediatric dental patients. Pediatric Dentistry. 1994;16(4):301–330
  47. Houpt MI, Weiss NJ, Koenigsberg SR, Desjardins PJ. Comparison of chloral hydrate with and without promethazine in the sedation of young children. Pediatric Dentistry. 1985;7(1):41–46
  48. Houpt MI, Sheskin RB, Koenigsberg SR, Desjardins PJ, Shey Z. Assessing chloral hydrate dosage for young children. ASDC Journal of Dentistry for Children. 1985;52(5):364–369
  49. Wilson S. Facial electromyography and chloral hydrate in the young dental patient. Pediatric Dentistry. 1993;15(5):343–347
  50. Abrams R, Morrison JE, Villasenor A, Hencmann D, Fonseca M, Mueller W. Safety and effectiveness of intranasal administration of sedative medications (ketamine, midazolam, or sufentanil) for urgent brief pediatric dental procedures. Anesthesia Progress. 1993;40(3):63–66
  51. Alfonzo-Echeverri EC, Berg JH, Wild TW, Glass NL. Oral ketamine for pediatric outpatient dental surgery sedation. Pediatric Dentistry. 1993;15(3):182–185
  52. Avalos-Arena V, Moyao-Garcia D, NavaOcampo AA, Zayaz-Carranza REZ, Fragoso-Rios R. Is chloral hydrate/hydroxyzine a good option for paediatric dental outpatient sedation?. Current Medical Research and Opinion. 1998;14(4):219–226
  53. Badalaty MM, Houpt M, Koenigsberg SR, Maxwell KC, Desjardins PJ. A comparison of chloral hydrate and diazepam sedation in young children. Pediatric Dentistry. 1990;12(1):33–37
  54. Bui T, Redden RJ, Murphy S. A comparison study between ketamine and ketamine–promethazine combination for oral sedation in pediatric dental patients. Anesthesia Progress. 2002;49(1):14–18
  55. Dallman JA, Ignelzi MA, Briskie DM. Comparing the safety, efficacy and recovery of intranasal midazolam vs. oral chloral hydrate and promethazine. Pediatric Dentistry. 2001;23(5):424–430
  56. Downs T, Dembo J, Ferreti G, Lyons TD, Pelphery A. A comparative study of midazolam to meperidine/promethazine as an IM sedative technique for the pediatric dental patient. ASDC Journal of Dentistry for Children. 1997;64(3):197–200
  57. Haas DA, Nenninger SA, Yacobi R, Magathan JG, Grad H, Copp PE, et al. A pilot study of the efficacy of oral midazolam for sedation in pediatric dental patients. Anesthesia Progress. 1996;43(1):1–8
  58. Hasty MF, Vann WF, Dilley DC, Anderson J. Conscious sedation of pediatric dental patients: an investigation of chloral hydrate, hydroxyzine pamoate, and meperidine vs. chloral hydrate and hydroxyzine pamoate. Pediatric Dentistry. 1991;13(1):10–19
  59. Houpt MI, Kupietzky A, Tofsky NS, Koenigsberg SR. Effects of nitrous oxide on diazepam sedation of young children. Pediatric Dentistry. 1996;18(3):236–241
  60. Jensen B, Schroder U, Mansson U. Rectal sedation with diazepam or midazolam during extractions of traumatized primary incisors; a prospective, randomized, double-blind trial in Swedish children aged 1.5–3.5 years. Acta Odontologica Scandinavia. 1999;57(4):190–194
  61. Lökken P, Bakstad OJ, Fonnelop E, Skogedal N, Hellsten K, Bjerkelund CE, et al. Conscious sedation by rectal administration of midazolam or midazolam plus ketamine as alternatives to general anesthesia for dental treatment of uncooperative children. Scandinavian Journal of Dental Research. 1994;102(5):274–280
  62. McCann W, Wilson S, Larsen P, Stehle B. The effects of nitrous oxide on behavior and physiological parameters during conscious sedation with a moderate dose of chloral hydrate and hydroxyzine. Pediatric Dentistry. 1996;18(1):35–41
  63. Musial KM, Wilson S, Preisch J, Weaver J. Comparison of the efficacy of oral midazolam alone vs midazolam and meperidine in the paediatric dental patient. Pediatric Dentistry. 2003;25(5):468–474
  64. Roelofse JA, Joubert JJ, Roelofse PG. A double-blind randomized comparison of midazolam alone and midazolam combined with ketamine for sedation of pediatric dental patients. Journal of Oral and Maxillofacial Surgery. 1996;54(7):838–844
  65. Roelofse JA, Joubert JJ, Swart LC, Stander I, Roelofse PG. An evaluation of the effect of oral ketamine and standard oral premedication in the sedation of paediatric dental patients. Journal of the Dental Association of South Africa. 1996;51(4):197–201
  66. Roelofse JA, Louw LR, Roelofse PG. A double-blind randomized comparison of midazolam alone and midazolam combined with ketamine for sedation of pediatric dental patients. Anesthesia Progress. 1998;45(1):3–11
  67. Sams DR, Cook EW, Jackson JG, Roebuck BL. Behavioral assessments of two drug combinations for oral sedation. Pediatric Dentistry. 1993;15(3):186–190
  68. Shapira J, Holan G, Guelmann M, Cahan S. Evaluation of the effect of nitrous oxide and hydroxyzine in controlling the behavior of the pediatric dental patient. Pediatric Dentistry. 1992;14(3):167–170
  69. Shapira J, Kupietzky A, Kadari A, Fuks AB, Holan G. Comparison of oral midazolam with and without hydroxyzine in the sedation of pediatric dental patients. Pediatric Dentistry. 2004;26(6):492–496
  70. Singh N, Pandey RK, Saksena AK, Jaiswal JN. A comparative evaluation of oral midazolam with other sedatives as premedication in pediatric dentistry. Journal of Clinical Pediatric Dentistry. 2002;26(2):161–164
  71. Songvasin C, Pasavorakul A. A comparison of the child's behavior between two groups of oral sedative drugs. Journal of the Dental Association of Thailand. 1990;40(6):237–245
  72. Tsinidou KG, Curzon ME, Sapsford DJ. A study to compare the effectiveness of temazepam and a chloral hydrate/hydroxyzine combination in sedating paediatric dental patients. International Journal of Paediatric Dentistry. 1992;2(3):163–169

PII: S0300-5712(06)00154-0

doi: 10.1016/j.jdent.2006.08.002

Journal of Dentistry
Volume 35, Issue 1 , Pages 2-20 , January 2007