Journal of Dentistry
Volume 34, Issue 8 , Pages 533-538, September 2006

In vitro biocompatibility of a novel Fe2O3 based glass ionomer cement

  • K. Hurrell-Gillingham

      Affiliations

    • Centre for Biomaterials & Tissue Engineering School of Clinical Dentistry, University of Sheffield Claremont Crescent, Sheffield S10 2TA, UK
    • Department of Engineering Materials, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK
    • ,
  • I.M. Reaney

      Affiliations

    • Department of Engineering Materials, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK
    • ,
  • I. Brook

      Affiliations

    • Centre for Biomaterials & Tissue Engineering School of Clinical Dentistry, University of Sheffield Claremont Crescent, Sheffield S10 2TA, UK
    • ,
  • P.V. Hatton

      Affiliations

    • Centre for Biomaterials & Tissue Engineering School of Clinical Dentistry, University of Sheffield Claremont Crescent, Sheffield S10 2TA, UK
    • Corresponding Author InformationCorresponding author. Tel.: +44 114 2717938; fax: +44 114 2665326.

Received 14 November 2004; accepted 18 July 2005.

Abstract 

Introduction

Since their invention in the late 1960s, glass ionomer cements (GICs) have been used extensively in dentistry but recently they have also been utilised in ear nose and throat (ENT) surgery. Unfortunately, Al3+, a component of conventional ionomer glasses, has been linked to poor bone mineralisation and neurotoxicity.

Objective

The aim of the research was to modify a commercial ionomer glass composition by substituting Al2O3 with Fe2O3.

Methods

Glasses with the following molar compositions were fabricated: 4.5SiO2·3M2O3·XP2O5·3CaO·2CaF2 (M=Al or Fe, X=0–1.5). The glasses were characterised using X-ray fluorescence (XRF) and X-ray powder diffraction (XRD). Cements were prepared using a standard ratio of; 1g of glass powder: 0.2g of dried polyacrylic acid: 0.3g of 10% tartaric acid solution. Cement formation was assessed using a Gilmore needle and in vitro biocompatibility was investigated for novel cement formulations.

Results

XRF revealed that the Fe2O3-based glasses had Al2O3 contamination from the crucibles and also had undergone substantial F− losses. XRD gave peaks that corresponded to magnetite Fe3O4 (JCPDS # 19-629) in all compositions. Apatite Ca5(PO4)3(OH,F) (JCPDS # 15-876) was identified in P2O5 containing glasses. It was possible to fabricate cements from all of the Fe2O3-based ionomer glasses. Good in vitro biocompatibility was observed for the Fe2O3-based cements.

Conclusion

Ionomer glasses may be prepared by entirely replacing Al2O3 with Fe2O3. Cement setting times appeared to be related to P2O5 content. Fe2O3-based cements showed good in vitro biocompatibility.

Keywords: Glass-ionomer cement, Aluminium free, Bone cement

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PII: S0300-5712(06)00038-8

doi:10.1016/j.jdent.2005.07.011

Journal of Dentistry
Volume 34, Issue 8 , Pages 533-538, September 2006

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