Efficacy of intraoral topical anesthetics in children

Summary 

Objectives

The literature reports mixed results regarding the efficacy of intraoral topical anesthetics. Only a few studies have been performed in children. Some non-placebo controlled studies have been carried out to compare the efficacy in reducing children's injection pain between different topical anesthetics

Methods

In a randomized, double blind, placebo controlled study with split-mouth design 104 children were enrolled to evaluate the efficacy of four topical anesthetics (Gingicain^® Spray, Gingicaine^® Topical Anesthetic, Legecain-Solution^®, EMLA^® Crème) when used prior to buccal injections within the conservative treatment of carious upper primary molars. The heart rate change and a Face Pain Scale were used as primary variables. The Visual Analog Scale, the modified Children's Hospital Pain Scale and the Sound-Eyes-Motor Scale were also evaluated.

Results

There was no significant difference between the placebo and any corresponding topical anesthetic with regard to the primary variables (HRC and FPS). A significant difference was found in favour of Gingicain® Spray and Gingicaine^® Topical Anesthetic according to secondary variables (VAS, S(E)MS).

Conclusion

While the secondary variables point to a benefit of the topical anesthetics Gingicain^® Spray and Gingicaine^® Topical Anesthetic compared to placebo, the results of the primary variables showed no differences in effectiveness of topical anesthetics and their corresponding placebos.

Keywords: Intraoral, topical, anesthetic, RCT, placebo